Research Acknowledgement

It is extremely important that our grant is cited in all publications resulting from the use of NORC services. Our productivity and effectiveness as a Center is measured in part by the citation of the grant in published work. Please use the following acknowledgement in your publications:

This work utilized Core Services supported by grant DK089503 of NIH to the University of Michigan.

Core Services: Molecular Phenotyping: Directed Metabolomics Lab

As a part of the Michigan Nutrition and Obesity Research center (MNORC), the Directed Metabolomics Core Laboratory provides the University of Michigan research community with the ability to perform quantitative assays for a wide variety of small molecules of biological origin (metabolites). The laboratory works with individual investigators to develop appropriate methods for metabolite analysis. We work with a wide range of sample types, including (but not limited to) cells, tissues, and biological fluids from human subjects, research animals, or other organisms. Typical assays we perform are listed below; however, our capabilities are by no means limited to the compound classes in the list. Please contact us with any inquiries about your analysis of interest.

View example data from selected assays.

Our primary analytical platforms are LC-MS/MS (triple quadrupole), LC-MS (time of flight), GC-MS (electron ionization and chemical ionization), and GC (flame ionization detection).

Rates

The Molecular Phenotyping Core of the Nutrition Obesity Research Center is offering the following at the indicated cost per sample. Prices apply to studies billed directly to a NORC member utilizing a University of Michigan internal account.

Rates for Directed metabolomics assays

  • Amino acid analysis (plasma/urine): $65.43 per sample
  • Amino acid analysis (with protein hydrolysis): $94.27 per sample
  • Short chain fatty acid analysis: $76.07 per sample
  • Acylcarnitine analysis (plasma): $80.66 per sample
  • Acyl-CoA analysis (tissue/cells): $80.66 per sample
  • Ceramide analysis (tissue/cells): $80.66 per sample
  • Glycolysis/TCA/Nucleotide analysis (tissue/cells): $83.38 per sample
  • NAD-related metabolyte analysis (tissue/cells): $83.38 per sample
  • 13C mass isotopomer analysis (13C flux analysis): $135.09 per sample
  • Bile acid analysis (colon contents/plasma): $95.62 per sample
  • Steroids sample preparation/instrument time: $74.30 per sample

Hourly rates (for new assays and services not listed above)

  • Develop Assay: $127.94 per hour
  • Sample Preparation Labor: $58.76 per hour
  • Data processing and presentation (beyond standard reporting included with sample analysis): $87.14 per hour

For larger sample batches, please contact us regarding bulk analysis rates.

Contact

U of M users: Please contact Steve Brown at stephecb@umich.edu or call 734-232-0842 to schedule these services. We request that a completed sample submission form be submitted with all samples (email or hardcopy are both acceptable).

External users: Please call or email for pricing schedule. 30% overhead must be included for all external users. A signed service agreement and hard copy of purchase order must be obtained from each outside customer.

For more information, please email Steve Brown at stephecb@umich.edu or call 734-232-0842.