Research Acknowledgement

It is extremely important that our grant is cited in all publications resulting from the use of NORC services. Our productivity and effectiveness as a Center is measured in part by the citation of the grant in published work. Please use the following acknowledgement in your publications:

This work utilized Core Services supported by grant DK089503 of NIH to the University of Michigan.

Core Services: Molecular Phenotyping

Director Subramaniam Pennathur, MD, PhD Medical School
Co-Director Robert Kennedy, PhD College of Literature, Science, and the Arts, Chemistry

The Molecular Phenotyping Core provides analytical tools to MMOC investigators to permit structural identification and quantification of metabolites as well as perform metabolic studies in in vitro systems. In addition to providing instrumental infrastructure, the Core staff will provide consultation and collaboration to apply metabolomics platforms in nutrition and obesity research.

Identification and quantification services are provided in association with the Michigan Regional Comprehensive Metabolomics Resource Center (MRC2) and the Biomedical Research Core Facilities (BRCF). These include:

  • metabolomic platforms for analysis of biospecimens derived from murine, rodent, human and plant sources as well as from primary and established cell lines and subcellular fraction.
  • assistance to Center Investigators in the experimental design and techniques to generate samples for metabolomic analysis.
  • facilitation of interaction between investigators with the Integrated Biostatistics and Informatics Core to integrate metabolomic and other molecular phenotyping into clinical, translational and population studies.
  • expertise and advice in the design, execution and analysis of studies using heavy isotope flux experiments for assessment of intermediary metabolism utilizing the metabolomic platform.
  • development of new techniques and technologies for molecular phenotyping in accordance with the needs of the MMOC investigators.
  • provide training in technologies related to molecular phenotyping.

More information on these services can be found at the MRC2 website: http://mrc2.umich.edu. Information on sample submission can be found at the BRCF Metabolomics Core page: http://medicine.umich.edu/medschool/research/office-research/biomedical-research-core-facilities/metabolomics.

In addition, the core provides the infrastructure, expertise and training for in vitro studies of cellular and mitochondrial metabolism via a Seahorse XF Analyzer.