Department of Human Genetics Seminar Series
New Players in the Histone Modification Network: A Link to Human Cognitive Disorders
Shigeki Iwase, Ph.D.
Division of Newborn Medicine and Epigenetics Program
Department of Medicine, Children’s Hospital Boston
Department of Cell Biology, Harvard Medical School
BSSP and Faculty Candidate
Department of Human Genetics
Dr. Shigeki Iwase has been studying the mechanisms underlying the regulation of gene expression in neuronal cells since his graduate work in the lab of Tadashi Baba at the University of Tsukuba in Japan. He discovered and characterized the BHC80 component of the BRAF-HDAC complex, which is involved in transcriptional repression in neurons, using cell biology and mouse genetic approaches, resulting in 2 first author publications. Currently a postdoctoral fellow in Yang Shi’s lab at Harvard Medical School, Dr. Iwase has been studying chromatin regulatory mechanisms with a focus on defects in histone methylation that lead to mental retardation. In another line of investivation, Dr. Iwase identified non-canonical mechanisms of methyl-histone recognition by a cysteine rich domain of ATRX, another X-linked mental retardation gene product. He intends on extending his postdoctoral work for his future research program to further elucidate the chromatin regulatory mechanisms underlying cognitive development and function.
Thursday, March 29, 2012
promptly at 10:30-11:30 AM
4917 Buhl (conference room)
1241 Catherine St.